New Anti-Parasitic Drugs for a Global Veterinary Market

Chromosome-contiguous nuclear genome of Dirofilaria asiatica reveals unique molecular signatures and host interactions

ND Young, Y Zheng, AV Koehler, T Wang, SB Sumanam, U Atapattu, BCH Chang, V Colella, RB Gasser

2025-12-01

Dirofilaria asiatica is a recently described filarioid nematode of zoonotic importance whose biology, host interactions and epidem..

Genome-Wide Inference of Essential Genes in Dirofilaria immitis Using Machine Learning

TL Campos, PK Korhonen, ND Young, SB Sumanam, W Bullard, JM Harrington, J Song, BCH Chang, RJ Marhöfer, PM Selzer, RB Gasser

2025-10-01

The filarioid nematode Dirofilaria immitis is the causative agent of heartworm disease, a major parasitic infection of canids, fel..

Chromosome-Contiguous Reference Genome for Spirometra to Underpin Future Discovery Research

ND Young, R Malik, A Brown, T Wang, A Ash, PK Korhonen, RB Gasser

2025-07-01

Sparganosis is a neglected food- and water-borne zoonotic disease caused by members of the tapeworm genus Spirometra. More than 16..

Chromosome-Contiguous Ancylostoma duodenale Reference Genome from a Single Archived Specimen Elucidates Human Hookworm Biology and Host–Parasite Interactions †

ND Young, Y Zheng, SB Sumanam, T Wang, J Song, BCH Chang, RB Gasser

2025-06-01

Soil-transmitted helminths (STHs) are parasitic nematodes that infect humans, particularly in tropical and subtropical regions, wh..

Analysis of Haemonchus embryos at single cell resolution identifies two eukaryotic elongation factors as intervention target candidates

PK Korhonen, T Wang, ND Young, JJ Byrne, TL Campos, BCH Chang, AC Taki, RB Gasser

2024-12-01

Advances in single cell technologies are allowing investigations of a wide range of biological processes and pathways in animals, ..

Chromosome-contiguous genome for the Haecon-5 strain of Haemonchus contortus reveals marked genetic variability and enables the discovery of essential gene candidates

Y Zheng, ND Young, TL Campos, PK Korhonen, T Wang, SB Sumanam, AC Taki, JJ Byrne, BCH Chang, J Song, RB Gasser

2024-11-01

Millions of livestock animals worldwide are infected with the haematophagous barber's pole worm, Haemonchus contortus, the aetiolo..

Structure activity relationship and target prediction for ABX464 analogues in Caenorhabditis elegans

HT Shanley, AC Taki, N Nguyen, T Wang, JJ Byrne, CS Ang, MG Leeming, S Nie, N Williamson, Y Zheng, ND Young, PK Korhonen, A Hofmann, TNC Wells, A Jabbar, BE Sleebs, RB Gasser

2024-01-15

Global challenges with treatment failures and/or widespread resistance in parasitic worms against commercially available anthelmin..

Genome-Wide Analysis of Haemonchus contortus Proteases and Protease Inhibitors Using Advanced Informatics Provides Insights into Parasite Biology and Host–Parasite Interactions

Y Zheng, ND Young, J Song, RB Gasser

2023-08-01

Biodiversity within the animal kingdom is associated with extensive molecular diversity. The expansion of genomic, transcriptomic ..

Genome-wide exploration reveals distinctive northern and southern variants of Clonorchis sinensis in the Far East

L Kinkar, PK Korhonen, U Saarma, T Wang, XQ Zhu, I Harliwong, B Yang, JL Fink, D Wang, BCH Chang, GN Chelomina, AV Koehler, ND Young, RB Gasser

2023-05-01

Clonorchis sinensis is a carcinogenic liver fluke that causes clonorchiasis—a neglected tropical disease (NTD) affecting ~35 milli..

An informatic workflow for the enhanced annotation of excretory/secretory proteins of Haemonchus contortus

Y Zheng, ND Young, J Song, BCH Chang, RB Gasser

2023-01-01

Major advances in genomic and associated technologies have demanded reliable bioinformatic tools and workflows for the annotation ..

Thermal proteome profiling reveals Haemonchus orphan protein HCO_011565 as a target of the nematocidal small molecule UMW-868

AC Taki, T Wang, NN Nguyen, CS Ang, MG Leeming, S Nie, JJ Byrne, ND Young, Y Zheng, G Ma, PK Korhonen, AV Koehler, NA Williamson, A Hofmann, BCH Chang, C Häberli, J Keiser, A Jabbar, BE Sleebs, RB Gasser

2022-10-14

Parasitic roundworms (nematodes) cause destructive diseases, and immense suffering in humans and other animals around the world. T..

Ubiquitination pathway model for the barber's pole worm – Haemonchus contortus

Y Zheng, G Ma, T Wang, A Hofmann, J Song, RB Gasser, ND Young

2022-08-01

The ubiquitin-mediated pathway has been comprehensively explored in the free-living nematode Caenorhabditis elegans, but very litt..

Novel High-Throughput Fluorescence-Based Assay for the Identification of Nematocidal Compounds That Target the Blood-Feeding Pathway

A Marchand, JWM Van Bree, AC Taki, M Moyat, G Turcatti, M Chambon, AAT Smith, R Doolan, RB Gasser, NL Harris, T Bouchery

2022-06-01

Hookworm infections cause a neglected tropical disease (NTD) affecting ~740 million people worldwide, principally those living in ..

A High-Throughput Phenotypic Screen of the ‘Pandemic Response Box’ Identifies a Quinoline Derivative with Significant Anthelmintic Activity

HT Shanley, AC Taki, JJ Byrne, A Jabbar, TNC Wells, K Samby, PR Boag, N Nguyen, BE Sleebs, RB Gasser

2022-02-01

Parasitic nematodes cause diseases in livestock animals and major economic losses to the agricultural industry worldwide. Nematode..

Dysidenin from the marine sponge citronia sp. Affects the motility and morphology of haemonchus contortus larvae in vitro

KS Ramage, AC Taki, KY Lum, S Hayes, JJ Byrne, T Wang, A Hofmann, MG Ekins, JM White, A Jabbar, RA Davis, RB Gasser

2021-12-01

High-throughput screening of the NatureBank marine extract library (n = 7616) using a phenotypic assay for the parasitic nematode ..

Phytochemical Profiling and Biological Testing of the Constituents of the Australian Plant Haemodorum brevisepalum

EO Norman, S Hombsch, J Lever, R Brkljača, J White, RB Gasser, AC Taki, S Urban

2021-11-26

Phytochemical profiling was undertaken on the crude extracts of the bulbs, stems, and the fruits of Haemodorum brevisepalum, to de..

High throughput screening of the naturebank ‘marine collection’ in a haemonchus bioassay identifies anthelmintic activity in extracts from a range of sponges from australian waters

AC Taki, JJ Byrne, A Jabbar, KY Lum, S Hayes, RS Addison, KS Ramage, A Hofmann, MG Ekins, T Wang, BCH Chang, RA Davis, RB Gasser

2021-10-01

Widespread resistance in parasitic nematodes to most classes of anthelmintic drugs de-mands the discovery and development of novel..

Practical high-throughput method to screen compounds for anthelmintic activity against caenorhabditis elegans

AC Taki, JJ Byrne, PR Boag, A Jabbar, RB Gasser

2021-07-02

In the present study, we established a practical and cost-effective high throughput screening assay, which relies on the measureme..

High-throughput phenotypic assay to screen for anthelmintic activity on haemonchus contortus

AC Taki, JJ Byrne, T Wang, BE Sleebs, N Nguyen, RS Hall, PK Korhonen, BCH Chang, P Jackson, A Jabbar, RB Gasser

2021-07-01

Parasitic worms cause very significant diseases in animals and humans worldwide, and their control is critical to enhance health, ..